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Illustrate the processes by which chylomicrons are metabolized by lipases to form chylomicron remnants, which are then removed from the circulation by the liver.Įxplain how VLDL is metabolized by lipases to VLDL remnants (also called intermediate-density lipoprotein ) which may be cleared by the liver or converted to low-density lipoprotein (LDL), which functions to deliver cholesterol from the liver to extrahepatic tissues and is taken up via the LDL (apoB100,E) receptor.Įxplain how high-density lipoprotein (HDL), which returns cholesterol from extrahepatic tissues to the liver in reverse cholesterol transport, is synthesized, indicate the mechanisms by which it accepts cholesterol from tissues, and show how it is metabolized in the HDL cycle. Phospholipids have a key role in the structure and properties of cell. Indicate the major types of apolipoprotein found in the different lipoprotein classes.Įxplain that triacylglycerol is carried from the intestine (after intake from the diet) to the liver in chylomicrons and from the liver to extrahepatic tissues in very low density lipoprotein (VLDL), and these particles are synthesized in intestinal and liver cells, respectively, by similar processes. Cholesterol and triglycerides are insoluble in water and therefore these lipids must be transported in association with proteins. Lipid is the collective name for fats, oils, waxes and fat-like molecules (such as. Illustrate the structure of a lipoprotein particle. ![]() Identify the four major groups of plasma lipoproteins and the four major lipid classes they carry. 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